Section for Molecular Epidemiology and Infections

The section's activities focus on molecular markers and infections related to the risk of cancer development and early detection, with the aim of improving cancer prevention.
Last updated: 11/1/2021

Our research is based on molecular data from biobanks, epidemiological data from health registries and screening programs, as well as data from questionnaire - and health surveys. Many of our projects are interdisciplinary and involve both epidemiological, molecular biological and clinical competence.

An important topic for our research is HPV-related cancer, and we have several projects on HPV vaccination and cervical cancer screening. Another main topic of the section is biomarker research based on biological material from the prospective population-based Janus Serum Bank, and other biobanks. We are also working on facilitating research collaborations between the Cancer Registry and the pharmaceutical industry, and with the development of statistical methods for analysing complex datasets.

Currently, the Section for molecular Epidemiology and Infections includes five senior researchers and seven postdoc and PhD students. The section is responsible for the management of several of the Cancer Registry's biobanks and laboratory facilities, and includes employees in research support, biobank management and laboratory functions.

We work closely with the other sections in the department, and with molecular epidemiological and clinical research environments both nationally and internationally.

Selected Publications

Townsend MK, Trabert B, Fortner RT, Arslan AA, Buring JE, Carter BD, Giles GG, Irvin SR, Jones ME, Kaaks R, Kirsh VA, Knutsen SF, Koh WP, Lacey JV, Langseth H, Larsson SC, Lee IM, Martínez ME, Merritt MA, Milne RL, O'Brien KM, Orlich MJ, Palmer JR, Patel AV, Peters U et al. (2021)
Cohort Profile: The Ovarian Cancer Cohort Consortium (OC3)
Int J Epidemiol (in press)
DOI 10.1093/ije/dyab211, PubMed 34652432

Gislefoss RE, Berge U, Lauritzen M, Langseth H, Wojewodzic MW (2021) 
A Simple and Cost-Effective Method for Measuring Hemolysis in Biobank Serum Specimens
Biopreserv Biobank
DOI 10.1089/bio.2021.0037, PubMed 34613836

Ramberg H, Richardsen E, de Souza GA, Rakaee M, Stensland ME, Braadland PR, Nygård S, Ögren O, Guldvik IJ, Berge V, Svindland A, Taskén KA, Andersen S (2021)
Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer
Carcinogenesis, 42 (5), 685-693
DOI 10.1093/carcin/bgab015, PubMed 33609362

Chen D, Grimsrud TK, Langseth H, Barr DB, Bassig BA, Blair A, Cantor KP, Gammon MD, Lan Q, Rothman N, Engel LS (2020)
Prediagnostic serum concentrations of organochlorine pesticides and non-Hodgkin lymphoma: A nested case-control study in the Norwegian Janus Serum Bank Cohort
Environ Res, 187, 109515
DOI 10.1016/j.envres.2020.109515, PubMed 32445944

Nygård MHansen BT, Kjaer SK, Hortlund M, Tryggvadóttir L, Munk C, Lagheden C, Sigurdardottir LG, Campbell S, Liaw KL, Dillner J (2020)
Human papillomavirus genotype-specific risks for cervical intraepithelial lesions
Hum Vaccin Immunother, 17 (4), 972-981
DOI 10.1080/21645515.2020.1814097, PubMed 32990181

Hektoen HH, Robsahm TE, Andreassen BK, Stenehjem JS, Axcrona K, Mondul A, Gislefoss RE (2020)
Lifestyle associated factors and risk of urinary bladder cancer: A prospective cohort study from Norway
Cancer Med, 9 (12), 4420-4432
DOI 10.1002/cam4.3060, PubMed 32319230

Kjaer SK, Nygård M, Sundström K, Dillner J, Tryggvadottir L, Munk C, Berger SEnerly E, Hortlund M, Ágústsson ÁI, Bjelkenkrantz K, Fridrich K, Guðmundsdóttir I, Sørbye SW, Bautista O, Group T, Luxembourg A, Marshall JB, Radley D, Yang YS, Badshah C, Saah A (2020)
Final analysis of a 14-year long-term follow-up study of the effectiveness and immunogenicity of the quadrivalent human papillomavirus vaccine in women from four nordic countries
EClinicalMedicine, 23, 100401
DOI 10.1016/j.eclinm.2020.100401, PubMed 32637895

Enerly EBerger S, Kjær SK, Sundström K, Campbell S, Tryggvadóttir L, Munk C, Hortlund M, Thomas Group, Joshi A, Saah AJ, Nygård M (2020)
Use of real-world data for HPV vaccine trial follow-up in the Nordic region
Contemp Clin Trials, 92, 105996
DOI 10.1016/j.cct.2020.105996, PubMed 32247041

Enerly E, Flingtorp R, Christiansen IK, Campbell S, Hansen M, Myklebust TÅ, Weiderpass ENygård M (2019)
An observational study comparing HPV prevalence and type distribution between HPV-vaccinated and -unvaccinated girls after introduction of school-based HPV vaccination in Norway
PLoS One, 14 (10), e0223612
DOI 10.1371/journal.pone.0223612, PubMed 31600341

Rounge TB, Lauritzen M, Erlandsen SE, Langseth H, Holmen OL, Gislefoss RE (2019)
Ultralow amounts of DNA from long-term archived serum samples produce quality genotypes
Eur J Hum Genet, 28 (4), 521-524
DOI 10.1038/s41431-019-0543-x, PubMed 31719661

Hansen BT, Kjaer SK, Arnheim-Dahlström L, Liaw KL, Juul KE, Thomsen LT, Frederiksen K, Elfström KM, Munk C, Nygård M (2019)
Age at first intercourse, number of partners and sexually transmitted infection prevalence among Danish, Norwegian and Swedish women: estimates and trends from nationally representative cross-sectional surveys of more than 100 000 women
Acta Obstet Gynecol Scand, 99 (2), 175-185
DOI 10.1111/aogs.13732, PubMed 31529491

Aasbø G, Solbrække KN, Waller J, Tropé A, Nygård MHansen BT (2019)
Perspectives of non-attenders for cervical cancer screening in Norway: a qualitative focus group study
BMJ Open, 9 (8), e029505
DOI 10.1136/bmjopen-2019-029505, PubMed 31471438

Nygård S, Lingjærde OC, Caldas C, Hovig E, Børresen-Dale AL, Helland Å, Haakensen VD (2019)
PathTracer: High-sensitivity detection of differential pathway activity in tumours
Sci Rep, 9 (1), 16332
DOI 10.1038/s41598-019-52529-3, PubMed 31704995

Gislefoss RE, Stenehjem JS, Hektoen HH, Andreassen BK, Langseth H, Axcrona K, Weiderpass E, Mondul A, Robsahm TE (2018)
Vitamin D, obesity and leptin in relation to bladder cancer incidence and survival: prospective protocol study
BMJ Open, 8 (3), e019309
DOI 10.1136/bmjopen-2017-019309, PubMed 29602840

Rounge TB, Umu SU, Keller A, Meese E, Ursin G, Tretli S, Lyle R, Langseth H (2018)
Circulating small non-coding RNAs associated with age, sex, smoking, body mass and physical activity
Sci Rep, 8 (1), 17650
DOI 10.1038/s41598-018-35974-4, PubMed 30518766

Langseth H, Gislefoss RE, Martinsen JI, Dillner J, Ursin G (2017)
Cohort Profile: The Janus Serum Bank Cohort in Norway
Int J Epidemiol, 46 (2), 403-404g
DOI 10.1093/ije/dyw027, PubMed 27063606