Gallbladder cancer (GBC) is a highly aggressive malignancy of the biliary tract and affects over 175,000 persons worldwide. While, GBC is relatively rare in Western Europe and the United states, it is highly prevalent in several countries in South-East Asia and South-America, where Chile has the highest incidence rate. Because most GBC-related deaths occur in low- to middle-income countries research into the disease has been limited.
The overall project aims are to significantly improve the early detection and accuracy of risk estimation of GBC by identifying and adequately consider geographical, environmental, lifestyle, ethnic, gender and molecular differences. The project is divided into eight work packages (WPs), where the Cancer Registry of Norway is responsible for WP3: Novel biomarkers for GBC risk prediction and early detection. Our project group will use the well-established small RNA sequencing protocol, to investigate if there are any early/pre-diagnostic changes in the small RNA in the blood serum compared to healthy controls. In addition, analysis DNA methylation and genotyping will be performed.
For further information on the projects partners and work packages please click here. (https://www.klinikum.uni-heidelberg.de/eulat-eradicate-gbc)
Dominique Scherer, Marcela Dávila López, Benjamin Goeppert, Sanna Abrahamsson, Rosa González Silos, Igor Nova, Katherine Marcelain, Juan C. Roa, David Ibberson, Sinan U. Umu, Trine Ballestad Rounge, Stephanie Roessler, and Justo Lorenzo Bermejo, 2020. “RNA Sequencing of Hepatobiliary Cancer Cell Lines: Data and Applications to Mutational and Transcriptomic Profiling”
Johannes Brägelmann, Carol Barahona Ponce, Katherine Marcelain, Stephanie Roessler, Benjamin Goeppert, Ivan Gallegos, Alicia Colombo, Verónica Sanhueza, Erik Morales, María Teresa Rivera, Gonzalo de Toro, Alejandro Ortega, Bettina Müller, Fernando Gabler, Dominique Scherer, Melanie Waldenberger, Eva Reischl, Felix Boekstegers, Valentina Garate-Calderon, Sinan U. Umu, Trine B. Rounge, Odilia Popanda, Justo Lorenzo Bermejo, 2020. “Epigenome-Wide Analysis of Methylation Changes in the Sequence of Gallstone Disease, Dysplasia, and Gallbladder Cancer”