The Janus material

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The Janus Serum Bank contains samples from 318 628 donors.  As of December 31st 2022, 118 405 cancer cases are registered among the Janus donors.  

The Janus samples originate from three different sources. In the 1970s–90s, a number of population-based health surveys for monitoring risk factors for cardiovascular diseases, were performed in Norway. About 90% of the Janus donors were recruited from five of those health surveys. Approximately 10% of the Janus cohort members origin from Red Cross blood donors living in Oslo and the surroundings. A small proportion of the samples (n ∼ 3 500) in the cohort are from donors that entered the cohort with a pre-diagnostic sample at one time point, were later diagnosed with cancer and donated a new diagnostic sample. For this subgroup, both pre-and post-diagnostic samples from the same individuals are available. See the table below for details. 

 

Characteristics

Men

Women

Total

Total donors included in the cohort

166 137

152 491

318 628

Average age at enrolment (years)

41

41

-

Number of individuals by sample origin

 

 

 

- Health Examination donors (Oslo 1, The Age 40 program Oslo, The Norwegian Counties Study, The Age 40 program all counties and TROFINN)

146 222

134 898

281 120

- Red Cross Blood donors

15 079

13 811

28 890

Number of donors by number of sample collection time points

 

 

 

Health examination donors

 

 

 

                      1

118 707

108 067

226 774

                      2

175 24

16 082

336 06

                      3

9 457

10 117

19 574

                      4

534

632

1 166

Red Cross Blood donors

 

 

 

                      1

5 213

5 971

11 184

                      2

3 066

2 940

6 006

                      3

1 929

1 620

3 549

                     4

4 871

3 280

8 151

 

All of Norway's 19 counties (before the devision in 2018) participated in the population-based health surveys. The illustration below shows the distribution of samples by each county. 

 

Geographical distribution of sample collection in the Janus Serum Bank 

From: Cohort Profile: The Janus Serum Bank Cohort in Norway Int J Epidemiol. 2016;46(2):403-404g. doi:10.1093/ije/dyw027 Int J Epidemiol 

 

The average age at enrollment for all Janus donors is 41 years. The largest proportion of samples are collected from persons that participated in health examinations in their 40s. In the Red Cross blood donor group the average age is 34. See table below for details on age at first sample donation.

 

 

Age at
first s
ample

All
Janus donors

%

Health examination
donors

%

Red Cross
blood
donors

%

Men 0-29

12 916

7.8

5 642

3.7

7 207

41.3

  30-39

26 986

16.3

21 808

14.5

5 438

31.2

  40-49

117 085

70.8

116 317

77.1

3 075

17.6

  50-59

3 308

2.0

2 107

1.4 

1 524

8.7

  60+

5 095

3.6

4 905

3.3

194

1.1

Total men

 

 

165 390

 

150 779

 

17 438

 
Women 0-29

11 774

7.8

5 033

3.6

6 682

45.8

  30-39

25 475

16.8

21 867

15.8

3 786

26.0

  40-49

106 276

70.1

104 775

75.8

2 579

17.7

  50-59

2 589

1.7

1 377

1.0

1 341

9.2 

  60+

5 447

3.6

5 258

3.8

193

1.3

Total Women  

151 561

 

138 310

 

14 581

 

 

Cancer statistics

Every year the Janus Serum Bank is merged with updated numbers from the Cancer Registry of Norway. Below you can find information about number of cancer cases in Janus donors by cancer type and illustrations of the most common and rare cancer types by sex.

2023-12-21_Tabell_Janus_Cancercases_2022.png

 

2023-12-21_Figur_Janus_Most_common_cancertypes.png

 

 

2023-12-21_Figur_Janus_Rare_cancertypes.png

 

Age-period-cohort model of the Janus cohort members

Here can you download the age-period-cohort model of the Janus cohort members. The table is modified from Langseth et al, International Journal of Epidemiology, 2017, Vol. 46, No. 2.