Last updated: 5/25/2021
The bias criteria is based on biological variation within and between individuals. If the percentage difference in component level between fresh and long term stored samples does not exceed the allowed bias, one may report the difference as negligible.
With new technology, the Janus material can be used in genetic studies. It has been demonstrated that the miRNA and DNA found in the samples are of sufficient quality to perform sequencing analyses.
| Type of variable | Component | Percent difference between fresh and long-term stored samples | Bias criteria | Comments | web link |
| Biochemical component | Sodium | + 3.9 | 0.3 | Sublimation | link |
| Potassium | + 26.4 | 1.8 | Leakage of potassium due to prolonged clotting time | link | |
| Calcium | + 7.4 | 0.8 | Instable | link | |
| Bilirubin | ̶ 59.4 | 10.0 | Light sensitive, instable | link | |
| Creatinine | ̶ 1.2 | 3.4 | Stable | link | |
| Uric acid | ̶ 7.6 | 4.8 | Relatively stable | link | |
| Iron | + 4.0 | 8.8 | Stable | link | |
| Metyl malonic acid | 0 | NA | Stable | link | |
| Homocystein | + 4.4 | 7.7 | Stable | link | |
| Proteins | Albumin | ̶ 1.9 | 1.3 | Stable | link |
| Ferritin | ̶ 18.5 | 5.0 | Instable | link | |
| Transferrin | + 8.2 | 1.3 | Instable | link | |
| Sex hormone binding globulin | + 7.1 | 11.1 | Stable | link | |
| Alanin aminotransferase | ̶ 73.4 | 12.0 | Instable | link | |
| Aspartat aminotrasferase | + 2.0 | 5.4 | Stable | link | |
| Creatinin kinase | ̶ 96.1 | 11.5 | Instable | link | |
| Immunoglobulin E | + 4.3 | NA | Stable | link | |
| Immunoglobulin G | + 1.0 | 4.3 | Stable | link | |
| Cystatin C | ̶ 3.3 | 3.4 | Stable | link | |
| Vitamins | Folate | ̶ 69.9 | 11.2 | Light sensitive, instable | link |
| Vitamin B12 | + 8.9 | 8.0 | Stable | link | |
| Hormones | Testosterone | + 24.4 | 5.8 | Possible changes in background population | link |
| Follicle stimulating hormon | + 4.6 | 5.1 | Stable | link | |
| Luteinizing hormone | + 1.9 | 7.8 | Stable | link | |
| Prolactin | ̶ 33.5 | 15.4 | Instable | link | |
| Thyroidea stimulating hormon | ̶ 13.2 | 8.4 | Instable | link | |
| Free Thyroxine | + 3.5 | 3.4 | Stable | link | |
| Lipids and lipoproteins | Cholesterol | + 5.6 | 4.1 | Stable, possible changes in the background population | link |
| High density lipoprotein cholesterol | ̶ 69.2 | 5.2 | Instable | link | |
| Low density lipoprotein cholesterol | + 31.3 | 6.8 | Stable | link | |
| Apoprotein A1 | + 12.0 | 3.7 | Stable | link | |
| Apoprotein B | + 22.3 | 6.0 | Stable | link | |
| Nucleic acids | DNA | NA | NA | Stable | link |
| miRNA | NA | NA | Stable | link |
