Trine Rounge started working at the Cancer Registry in 2012. Her research interest is in epigenomics and development of cancer biomarkers. Her overall research goal is to identify DNA and/or RNA patterns from tissue, bio fluids or associated microbes that reveals cancer progression at an early stage.
She has a broad background in molecular biology and genomics, including wet-lab and bioinformatics, and she is well suited for running large-scale data-driven biomarker discoveries. Rounge’s expertise is in designing and establishing next generation sequencing protocols and the subsequent bioinformatics.
Together with Hilde Langseth, Trine is the PI of a large-scale project aiming to identify circulating sncRNAs cancer biomarkers using serum samples, funded by the Norwegian Research Council. The research group have developed a sncRNA sequencing protocol tailored for low RNA yield samples and done extensive characterization of sncRNA profiles of healthy individuals and confounding variables. In this project, they have profiled pre-diagnostic samples from seven different cancer sites. In total, more than 3000 samples have been analysed. Bioinformatic, regression and machine learning methods are applied.
Trine also works with projects related to genome-wide differential DNA methylation in three different projects and is the PI of a project funded by the Norwegian cancer Society, aiming to identify biomarkers in the gut microbiome for use in colorectal cancer screening.
She is also one of the leaders in a cross-institutional group that works with development of methods and analyses of genomic events and variation in persistent infection of Human Papillomavirus, with aim to discover if the accumulation of these events can be used in cervical cancer screening.
Trine received her PhD from the Faculty of Mathematics and Natural Sciences at the University of Oslo, Norway, in 2008. Her thesis was on the genomics and population dynamics of the freshwater cyanobacteria Planktohrix and their ability to build peptides using non-ribosomal pathways.
She remained in the same research centre as a postdoctoral fellow from 2008 to 2012, sequencing, de novo assembling and annotating the genome of the Atlantic cod, including an in-depth analyses of the cod immune system.
Projects: (engelske web-sider)
HPV SEKVENSERING FOR BIOMARKØRER – eng web-page
Fehlmann T, Backes C, Alles J, Fischer U, Hart M, Kern F, Langseth H, Rounge T, Umu SU, Kahraman M, Laufer T, Haas J, Staehler C, Ludwig N, Hübenthal M, Meder B, Franke A, Lenhof HP, Meese E, Keller A (2018)
A high-resolution map of the human small non-coding transcriptome
Bioinformatics, 34 (10), 1621-1628
Dube Mandishora RS, Gjøtterud KS, Lagström S, Stray-Pedersen B, Duri K, Chin'ombe N, Nygård M, Christiansen IK, Ambur OH, Chirenje MZ, Rounge TB (2018)
Intra-host sequence variability in human papillomavirus
Papillomavirus Res, 5, 180-191
Raju SC, Lagström S, Ellonen P, de Vos WM, Eriksson JG, Weiderpass E, Rounge TB (2018)
Reproducibility and repeatability of six high-throughput 16S rDNA sequencing protocols for microbiota profiling
J Microbiol Methods, 147, 76-86
Umu SU, Langseth H, Bucher-Johannessen C, Fromm B, Keller A, Meese E, Lauritzen M, Leithaug M, Lyle R, Rounge TB (2017)
A comprehensive profile of circulating RNAs in human serum
RNA Biol, 15 (2), 242-250
Keller A, Rounge T, Backes C, Ludwig N, Gislefoss R, Leidinger P, Langseth H, Meese E (2017)
Sources to variability in circulating human miRNA signatures
RNA Biol, 14 (12), 1791-1798