Trine B. Rounge

Section leader, Integrative Cancer Genomics

Research areas/interests:

Trine Rounge is the leader of the section Integrative Cancer Genomics. She started working at the Cancer Registry in 2012. Her research interest is in genomics, epigenomics, transcriptomics, microbiome research and development of cancer biomarkers. Her overall research goal is to identify DNA and/or RNA patterns from tissue, bio fluids or associated microbes that reveals cancer progression at an early stage.

Trine has a broad background in molecular biology and genomics, including wet-lab and bioinformatics, and she is well suited for running large-scale data-driven biomarker discoveries. Rounge's expertise is in designing and establishing next generation sequencing protocols and the subsequent bioinformatics.

Together with Hilde Langseth, Trine is the PI of a large-scale project aiming to identify circulating RNAs cancer biomarkers using serum samples, funded by the Norwegian Research Council - JanusRNA. The research group have developed a small RNA sequencing protocol tailored for low RNA yield samples and done extensive characterization of RNA profiles of healthy individuals and confounding variables. In this project, they have profiled pre-diagnostic samples from seven different cancer sites. In total, more than 4000 samples have been analysed. Bioinformatic, regression and machine learning methods are applied. She also works with projects related to genome-wide differential DNA methylation in three different projects.

Trine is the PI of the project CRCbiome funded by the Norwegian cancer Society, aiming to identify biomarkers in the gut microbiome for use in colorectal cancer screening. In collaboration with Paula Berstad they lead an effort to elucidate the interplay between the microbiome, lifestyle, diet and medication use on colorectal cancer development.

She is also one of the leaders in a cross-institutional group that works with development of methods and analyses of genomic events and variation in persistent infection of Human Papillomavirus, with aim to discover if the accumulation of these events can be used in cervical cancer screening.
Trine is an Associate Professor II at Centre for Bioinfomatics, Department of Informatics, University of Oslo.

Education/background:

Trine received her PhD from the Faculty of Mathematics and Natural Sciences at the University of Oslo, Norway, in 2008. Her thesis was on the genomics and population dynamics of the freshwater cyanobacteria Planktohrix and their ability to build peptides using non-ribosomal pathways.
She remained in the same research centre as a postdoctoral fellow from 2008 to 2012, sequencing, de novo assembling and annotating the genome of the Atlantic cod, including an in-depth analyses of the cod immune system.

Projects:  

CRCbiome - The microbiome as a colorectal cancer screening biomarker 

Sequencing HPV for biomarker discovery 

Small non-coding RNA as early detection cancer biomarkers

Small non-coding RNA forum

FIN-HIT http://www.finhit.fi/research-group/ 

Selected publications:

Umu SU, Langseth H, Keller A, Meese E, Helland Å, Lyle R, Rounge TB (2019)
A 10-year prediagnostic follow-up study shows that serum RNA signals are highly dynamic in lung carcinogenesis
Mol Oncol (in press)
DOI 10.1002/1878-0261.12620, PubMed 31851411

Rounge TB, Lauritzen M, Erlandsen SE, Langseth H, Holmen OL, Gislefoss RE (2019)
Ultralow amounts of DNA from long-term archived serum samples produce quality genotypes
Eur J Hum Genet (in press)
DOI 10.1038/s41431-019-0543-x, PubMed 31719661
 

Bucher-Johannessen C, Page CM, Haugen TB, Wojewodzic MW, Fosså SD, Grotmol T, Haugnes HS, Rounge TB (2019)
Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome
Clin Epigenetics, 11 (1), 179
DOI 10.1186/s13148-019-0764-4, PubMed 31796056

Raju SC, Lagström S, Ellonen P, de Vos WM, Eriksson JG, Weiderpass E, Rounge TB (2019)
Gender-Specific Associations Between Saliva Microbiota and Body Size
Front Microbiol, 10, 767
DOI 10.3389/fmicb.2019.00767, PubMed 31024514

Lagström S, Umu SU, Lepistö M, Ellonen P, Meisal R, Christiansen IK, Ambur OH, Rounge TB (2019)
TaME-seq: An efficient sequencing approach for characterisation of HPV genomic variability and chromosomal integration
Sci Rep, 9 (1), 524
DOI 10.1038/s41598-018-36669-6, PubMed 30679491