Digital public defence: Madleen Orumaa

MSc Madleen Orumaa at Institute of Clinical Medicine will be defending the thesis "Time trends of selected HPV-related diseases in Norway and the impact of HPV multi-cohort vaccination using real-world data from population-based registries" for the degree of PhD (Philosophiae Doctor).

Time and place

Sep. 3, 2020 10:30 AM, Zoom

The public defence will be held as a video conference over Zoom.

The digital defence will follow regular procedure as far as possible, hence it will be open to the public and the audience can ask ex auditorio questions when invited to do so.

Read more about the digital public defende at the University of Oslo web page

Digital Trial lecture

September 3rd 2020, 08:30 AM, Zoom

"Epidemiology and prevention of anal cancer: analogies with elimination of cervical cancer as a public health problem"

Adjudication committee

First opponent: Professor Suzanne Marie Garland, University of Melbourne Medical School, Australia

Second opponent: Group Head Gary Clifford, International Agency for Research on  Cancer, World Health Organization, Lyon, France

Third member and chair of the evaluation committee: Associate Professor Tone Kristin Omsland, Institute of Health and Society, University of Oslo

Chair of defence

Professor Emeritus Per Nafstad, Institute of Health and Society, University of Oslo

Principal supervisor

Mari Nygård, Cancer Registry of Norway, Oslo


Infection with human papillomavirus (HPV) is very common, and there are hundreds of different HPV types.

The majority of these types are harmless and may cause warts on hands, feet, and genitals, while some types may cause cancer after persistent infection. Increasing trends in the incidence of cervical precancer and HPV-related cancer have been attributed to increasing exposure to HPV in the population.

Vaccines against HPV infection which may cause cancer or genital warts have been available for more than ten years and they have shown high effectiveness against persistent HPV infection, cervical precancer and genital warts. 

The data analyzed in this thesis was obtained from eight Norwegian and four Danish high-quality population-based registries.

The overall aim of this thesis was to investigate temporal trends in the epidemiology of three HPV-related diseases (cervical precancer, penile cancer, and genital warts) in Norway.  In addition, the impact of HPV multi-cohort vaccination was investigated by comparing incidence trends of genital warts between Norway and Denmark.